Role of transmission electron microscopy in diagnosis of cryoglobulinemia related glomerulo- nephritis
- VernacularTitle:透射电镜检查在冷球蛋白血症肾损害诊断中的作用
- Author:
Suxia WANG
;
Wanzhong ZOU
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Cryoglobulinemia;
Kidney disease;
Microscopy,electron;
Organized deposits
- From:
Chinese Journal of Nephrology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of transmission electron microscopy (TEM) on the diagnosis of cryoglobulinemia related glomerulonephritis. Methods Sixteen cases which showed glomerular organized deposits by TEM in the renal biopsy specimens were collected in our hospital during last six years. Their clinical data, renal pathological features and ultrastructural morphology were analysed. Results Four cases had positive serum cryoglobulin were diagnosed as cryoglobulinemia related glomerulonephritis. Serum cryoglobulin was not available in the other 12 cases, who were suspected as cryoglobulinemia related glomerulonephritis. All patients had proteinuria with microscopic hematuria,and some cases had nephrotic syndrome, hypertension and mild to moderate renal insufficency. The main pathological pattern was membranoproliferative glomerulonephritis.Endocapillary proliferation with an infiltration of monocytes was observed in these cases. Glomerular subendothelial deposits and intraluminal thrombi was their prominent features. Organized electron-dense deposits were identified by TEM, whose deposits organized into microtubular, fibrillary, crystalline-like and granular structures, and were demonstrated mainly in glomerular subendothelia and capillary lumen. Most of cases were considered as cryoglobulinemia related glomerulonephritis by the ultrastructural findings of glomerular organized deposits. Conclusion Glomerular organized deposits identified by TEM provide important diagnostic implications for cryoglobulinemia related glomerulonephritis.
