Nordy inhibits the expression of vascular endothelial growth factor and inducible nitric oxide synthase in diabetic rat retinas
- VernacularTitle:诺帝抑制糖尿病大鼠视网膜VEGF和iNOS的表达及意义
- Author:
Chao DAI
;
Xiuwu BIAN
;
Jingquan SHI
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
vascular endothelial growth factor;
inducible nitric oxide synthase;
Nordy
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects and significance of Nordy on the expression of vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in the retinas of diabetic rats. Methods Diabetic rats by streptozotocin were randomly divided into diabetes group (5 rats?2) and Nordy treatment group (5 rats?2). Another 10 normal rats were recruited as normal control group. The Nordy treatment group was injected 0.5% Nordy (27 mg/kg) while diabetes groups and normal control group were injected saline solution into peritoneal cavity once every other day. One month or 3 months later, 5 rats in each group were killed and the expression of VEGF and iNOS in the retinas were detected by immunohisochemistry. The average positive areas were measured and analyzed by computer aided video system. Results The expression of VEGF and iNOS in control group were extremely low. In 1 month, the expression of VEGF and iNOS in diabetic group increased and the average positive areas of VEGF and iNOS were significantly more than that of Nordy treatment group (P
