Loss of heterozigosity of nm23-H_1 gene might induce lymph node metastasis in no-small-cell lung cancer
- VernacularTitle:非小细胞肺癌nm23-H_1等位基因缺失与淋巴结转移关系的研究
- Author:
Tonghua MEI
;
Changyi LI
;
Ailon HUANG
- Publication Type:Journal Article
- Keywords:
nm23-H_1 gene;
lung carcinoma;
neoplasm metastasis
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the loss of the heterozygosity of nm23-H_1 and the lymph node metastasis in no-small-cell lung cancer (NSCLC). Methods The loss of the heterozygosity of nm23-H_1 gene of cancer tissue and peri-cancerous tissue was detected in 39 patients with NSCLC by Southern blotting. Results The heterozygosity gene of nm23-H_1 is 7.6 kb and 2.3 kb. The LOH rate of the patients with lymph node metastasis (48%, 12/25) was higher than those without lymph node involvement (8%, 1/11) (P
