The inhibitory effect of dexamethasone on the expression of IL-1?in the lung and the visceral sensory afferent system of asthmatic guinea pigs
- VernacularTitle:地塞米松对哮喘豚鼠肺及内脏感觉传入部位IL-1?表达的抑制作用
- Author:
Deshou CAO
;
Hao TONG
;
Xiaoxiang LIU
;
Li LIU
;
Xiubin FANG
- Publication Type:Journal Article
- Keywords:
interleukin-1beta;
dexamethasone;
lung;
spinal ganglia;
spinal cord;
asthma
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the inhibitory effect of dexamethasone on the expression of IL-1? in the lung and the visceral sensory afferent system(C_7-T_5 spinal ganglia and the corresponding posterior horn of the spinal cord) of asthmatic guinea pigs. Methods Experimental asthma model of guinea pigs was induced by ovalbumin in vivo. The expression of IL-1? was detected by means of immunohistochemistry in the C_7-T_5 spinal ganglia and the corresponding posterior horn of the spinal cord of all guinea pigs. The expression of IL-1? protein was investigated by Western blot in the lung, C_7-T_5 spinal ganglia and the corresponding posterior horn of the spinal cord of all guinea pigs. Results The expression of IL-1? in the lung, C_7-T_5 spinal ganglia and the corresponding posterior horn of the spinal cord of the asthmatic guinea pigs was much higher than that of the control groups(P
