Effect of spinal substance P on the artinociceptive propoties of ketamine
- VernacularTitle:鞘内注射P物质拮抗氯胺酮的抗伤害作用
- Author:
Hong WANG
;
Fengqi LIU
;
Tijun DAI
;
Shiming DUAN
;
Yinming ZENG
- Publication Type:Journal Article
- Keywords:
ketamine;
substance P;
antagonize;
antinociceptive effect;
fos expression
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of spinal substance P on the antinociceptive propoties of ketamine. Methods Using behaviors and Fos expression technique,the effects of intrathecal administration (it) of substance P of different dose on the ketamine induced antinociception were observed in the formalin test of mice. Results Compared with NS group, the amount of time that mice spent licking the injected paw was dose-dependently decreased in 20 and 30 mg?kg -1 groups(P
