Pharmacokinetic-pharmacodynamic modeling of irbesartan in healthy Chinese adult volunteers
- VernacularTitle:厄贝沙坦在健康志愿者体内的药代动力学-药效学结合模型
- Author:
Xiaohui HUANG
;
Furong QIU
;
Jun LI
- Publication Type:Journal Article
- Keywords:
irbesartan;
pharmacokinetic;
pharmacodynamic
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the combined pharmacokinetic-pharmacodynamic(PK-PD) model of irbesartan in healthy Chinese male volunteers. Methods Eighteen healthy male volunteers received 300 mg irbesartan tablet orally. The plasma drug concentration (C_p) was determined by HPLC and pharmacologic effects, including SBP, DBP and HR, were measured simultaneously. The pharmakinetic and PK-PD model parameters were calculated. Results The pharmacokinetic profiles were best fitted a two-compartment open model. There was a hysteresis loop between effects and plasma concentrations. The relationship between effects and effect compartment concentrations of drugs could be represented by the Sigmoid-E_ max model. Conclusion We successfully eatablished the PK-PD model of irbesartan in healthy male volunteers. These findings may provide a more rational basis for patient-specific dosage individualization.
