Protective effect of Tet on cytotoxicity-induced by Qinolinic acid in cultured hippocampal neurons of new-brone rats
- VernacularTitle:粉防己碱对喹啉酸致海马神经元损伤的保护作用
- Author:
Lixia ZHU
- Publication Type:Journal Article
- Keywords:
tetrandrine;
hippocampal neurons;
quinolinic acid;
excitotoxicity
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the protection of tetrandrine(Tet) from the excitotoxicity of quinolinic acid(QA) on the cultured hippocampal neurons of new-borne rats.Method Excitoxocity injury was induced by QA in cultured hippocampal neurons.The cell viability was measured by MTT assay, extracellular LDH contents were also measured and the pathomorphology of neurons was observed. Result Tet with 10 -6 mol?L -1 and 10 -7 mol?L -1 could significantly blunt the death of the primary hippocampal neurons induced by QA,prevent leakage of LDH and improve the pathomorphology of neurons. Conclusion Tet (10 -6 mol?L -1 and 10 -7 mol?L -1)provids protection on QA induced cytotoxicity in cultured hippocampal neurons of new-borne rats.
