The study on inhibitory effects and mechanism of Maoeryan vegetable acid on human SGC-7901 strain cells
- VernacularTitle:猫儿眼植物酸对人SGC-7901细胞增殖的影响及其机制探讨
- Author:
Farong YU
;
Shutao FENG
;
Xiuzhen LIAN
;
Mingren XIE
- Publication Type:Journal Article
- Keywords:
Maoeryan vegetable acid;
human SGC-7901 strain cells;
flow cytometry;
methods of MTT;
methods of trypan-blue
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the inhibitory effect of Maoeryan vegetable acid on human SGC-7901 strain cells and the mechamism of it. Methods The inhibitory effects of Maoeryan vegetable acid on human SGC-7901 strain cells were determined by flow cytometry, methods of MTT and trypan-blue.Results Maoeryan vegetable acid at a does of 10.0, 1.0 and 0.1 mg?L -1 was given to human SGC-7901 strain cells for 48 h,respectively, and the inhibitory rate of human SGC-7901 strain cells was 82.9%,42.7% and 24.6%,respectively;cellular growth inhibitory rate was 76.4%,56.9% and 42.6%, respectively;as well as apoptosis rate was 26.8%,22.5% and 15.6%, respectively. Conclusion The Maoeryan vegetable acid has significant inhibitory effect on human SGC-7901 strain cells and the inhibitory effect increases with the increase of concentration and time.
