The investigation of mother-to-child transmission of Type-1 Human Immunodeficiency Virus
- VernacularTitle:中国某地区人类免疫缺陷病毒母婴传播与阻断的调查研究
- Author:
Liping DENG
;
Xien GUI
;
Ke ZHUANG
- Publication Type:Journal Article
- Keywords:
HIV infections;
AIDS;
Children;
Disease transmission, vertical;
Hepatitis,viral,human;
China
- From:
Chinese Journal of Infectious Diseases
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate mother-to-child transmission of HIV-1 and the factors that affect transmission. Methods 136 children who were born to HIV positive mothers in a high HIV prevalence region were interviewed and blood samples were examined for anti-HIV anti-HGV and HIV RNA or HIV DNA. Results Among 136 children who were born to HIV positive mothers, 50 were infected with HIV. The MTCT rate was 36.8% (50/136). Thirty eight DNA fragments of HIV-1 gag gene P17 obtained from HIV-1 seropositive mothers were amplified by PCR from uncultured peripheral blood mononuclear cells (PBMCs). Sequence analyses showed that all of them were HIV-1 B subtype. The HIV vertical transmission rate among mothers with AIDS (67.4%, 31/46) was significantly greater than among those with HIV alone (21.1%, 19/90), P
