Antitumor effects of novel thymidylate synthase inhibitor ZD1694 in vitro and in vivo
- VernacularTitle:新一代胸苷酸合成酶抑制剂ZD1694的体内外抗肿瘤作用
- Author:
Ling LI
;
Surong YANG
;
Minghui YAO
- Publication Type:Journal Article
- Keywords:
ZD1694;
tumor-bearing mice;
SGC-7901 gastric gland carcinoma cell line;
MTT assay;
flow cytometry
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
10 mg?kg -1?d -1? 5 d. The inhibitory rate of ZD1694( 0.001- 1 000 mmol?L -1)on SGC-7901 cells were increased in concentration and time-dependent manner. The cell numbers in G_0-G_1 phase in SGC-7901 cells were raised by ZD1694 as well. CONCLUSION: ZD1694 can take obvious antitumor effects on S180-bearing mice. The antitumor rate of ZD1694 is in a dose-dependent manner, and it is higher when the total dosage is administered in one day than that the total dosage was divided into 5 consecutive days. ZD1694 can inhibit the growth of SGC-7901 cells and block the cells in G_1 phase in vitro.
