EFFECTS OF TEA POLYSACCHARIDES ON GLUCOSE METABOLISM AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA IN KKAy TYPE 2 DIABETIC MICE
- VernacularTitle:茶多糖对KKAy糖尿病小鼠葡萄糖代谢和过氧化物增殖体激活型受体-?活性的影响
- Author:
Changyong XUE
;
Jihong QIU
;
Junying TENG
;
Yanghong OU
;
Zixin ZHENG
;
Rongxin ZHANG
- Publication Type:Journal Article
- Keywords:
tea polysaccharides;
KKAy diabetic mice;
peroxisome proliferator-activated receptor ?
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of green tea polysaccharides (TPs) on glucose metabolism and the activity of peroxisome proliferator-activated receptor gamma (PPAR-?) in KKAy type 2 diabetic mice. Methods: Glucose tolerance test, fasting and postprandial glucose, gluconeogenesis, and insulin sensitivity were investigated in type 2 diabetic mice with orally administered TPs at the dose of 500mg/kg for 4-10 w. Effect of TPs on activity of PPAR-? was tested in vitro. Results: TPs could not only improve glucose tolerance, but also reduce fasting and postprandial blood glucose. In addition, TPs could inhibit gluconeogenesis and enhance insulin sensitivity in KKAy diabetic mice. TPs had also an effect of activating of PPAR-? with dose-response. Conclusion: TPs have beneficial effect of lowering blood glucose in KKAy type 2 diabetic mice, which may be induced by enhancing insulin sensitivity by activating of PPAR-?.
