THE CHEMOPROPHYLACTIC EFFECTS OF PROCYANIDINS FROM LOTUS SEEDPOD ON DMBA-INDUCED BUCCAL-POUCH CARCINOMAS IN GOLDEN HAMSTERS
- VernacularTitle:莲房原花青素对二甲基苯芘蒽诱发金黄地鼠口腔癌的预防作用
- Author:
Xiaofen DU
;
Bijun XIE
;
Erning YANG
;
Zhida SUN
;
Shiqi ZHOU
- Publication Type:Journal Article
- Keywords:
procyanidins from Lotus Seedpod;
oral carcinoma;
chemoprophylactic
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the contents and constituents of LSPC (procyanidins from Lotus Seedpod) and its chemoprophylactic effects on 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced golden hamsters buccal-pouch carcinomas. Methods: ESI-MS was used to analyze LSPC, and the change of body weight, mortality during test, and the value of serum MDA, GSH-Px, T-SOD,the gross and pathological change of buccal-pouch mucosa were investigated when golden hamsters were via gastric intubation or the buccal pouch mucosa was smeared with 100mg/(kg bw?d)LSPC. Results and conclusion: The contents of LSPC exceeded 98% and mono-, di-, tri-, tetrameric procyanidins as well as di-, trimeric galic ester were constituted of LSPC with molecular weight ranging from 290-1154. LSPC had chemoprophylactic effects on DMBA-induced golden hamsters buccal-pouch carcinomas, and the effect was superior through smearing LSPC rather then via gastric intubation .
