Effects of GLP-Ⅱ pretreatment on mouse intestinal mucosal immunity after ischemia/reperfusion insult
- VernacularTitle:预防性应用类高血糖素多肽-Ⅱ对缺血-再灌注肠黏膜屏障的影响
- Author:
Hang LI
;
Ji CHEN
;
Guohao WU
- Publication Type:Journal Article
- Keywords:
Glucagon like peptide-Ⅱ;
Mucosal barrier;
Ischemia/reperfusion;
Mouse
- From:
Parenteral & Enteral Nutrition
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the protections of GLP-Ⅱ pretreatment on mouse intestinal mucosal immunity after ischemia/reperfusion insult. Methods: Thirty ICR mice were randomly divided into three groups: namely normal control (N), control (C) and GLP-Ⅱ pretreatment (P). Group C and group P were inflicted with ligation of superior mesenteric artery for twenty minutes. The morphology of distal ileum mucosa, the rate of intestinal bacteria translocation, the level of plasma endotoxin and intestinal IgA were determined. Results: After ischemia/reperfusion insult, there were obvious damage at distal ileum mucosa in group C and obvious proliferation in group P.The rate of intestinal bacteria translocation and the level of plasma endotoxin were significantly increased (P
