Relation between the expression of sIL-2R and the relapse in patients with acute lymphoblastic leukemia
- VernacularTitle:血清可溶性白细胞介素2受体表达与急性淋巴细胞性白血病复发的关系
- Author:
Jin LIU
;
Dengshu WU
;
Shen ZHANG
;
Chenhua YAN
;
Yu ZHOU
;
Yongding ZHANG
;
Zhenhu QI
- Publication Type:Journal Article
- Keywords:
Leukemia, lymphoblastic, acute;
Receptors, interleukin-2;
Recurrence
- From:
Journal of Peking University(Health Sciences)
2004;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relation of the serum level of sIL-2R in relapse patients with acute lymphoblastic leukemia(ALL). Methods:With ELISA, we determined the levels of sIL-2R of 48 patients with ALL after their first diagnoses,complete remission 1 and relapse. The levels of sIL-2R of 30 patients from complete remission 1 to relapse were monitored. Results: The levels of sIL-2R were higher in the relapse group and first diagnosed group than in the control. The levels of sIL-2R were higher in the relapse group and first diagnosed group than in the complete remission 1 group. However,the difference between the complete remission 1 and the control had no statistical significance. When we determined the levels of sIL-2R dynamically, we found that after complete remission ,the levels of sIL-2R decreased,however, before one month of hematological relapse, the levels of sIL-2R increased. Conclusion: Monitor of the level of sIL-2R can predict impending relapse of patients with ALL and is helpful to early diagnosis of relapse.
