Relationship and significance of HIF-1α and bcl-XL in gastric cancer
- VernacularTitle:胃癌缺氧诱导因子-1α与bcl-XL表达的关系
- Author:
Wei SUN
;
Qiang WANG
;
Ying ZHAO
;
Youwei KOU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Hypoxia-inducible factor 1,Alpha subunit;
bcl-X protein;
Immunohistochemistry;
Apoptosis
- From:
Cancer Research and Clinic
2008;20(3):165-167,171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of HIF-1α and bcl-XL in gastric cancer and their relationship with tumor angiogenesis,clinicopathologic feature and prognosis.Methods Immunohistochemical technique was used to detect the expression of HIF-1α and bcl-XL in 54 cases of gastric canoer.SPSS 12.0 software was used to analyze the relationship between the expression of HIF-1α, bcl-XL and tumor angiogenesis,clinicopathologic feature of patients.Results The positive expression rate of HIF-1α in gastric cancer(74.07%) was significantly higher than that in normal gastric tissue(0),P＜0.01;The expression of HIF-1α in gastric cancer was significantly associated with TNM stage,invasive depth and lymph-node metastasis,P＜0.05 or P＜0.01;The positive expression rate of bcl-XL in gastric cancer(53.7%) was significantly higher than that in normal gastric tissue(33.3%),P＜0.05;The expression of bcl-XL in gastric cancer was significantly associated with histological types,TNM stage and lymph-node metastasis,P＜0.05;There was a positive correlation between expression of HIF-1α and bcl-XL (r=0.41,P＜0.05).Conclusion HIF-1α and bcl-XL play a very important role in the development in gastric cancer and could be a factor in diagnosis of gastric cancer and estimation of prognosis.
