Investigation on the dissolution rates of glibenclamide and metformin in compound metformin hydrochloride
- VernacularTitle:复方盐酸二甲双胍片中格列本脲和二甲双胍溶出度的考察
- Author:
Ying SHI
;
Songqing LIU
- Publication Type:Journal Article
- Keywords:
glibenclamide;
metformin;
dissolution rate;
HPLC method
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dissolution rates of glibenclamide and metformin in compound metformin hydrochloride. Methods The concentrations of the glibenclamide and metformin were determined by HPLC method. The rotating basket method was used to measure and compare the dissolution rates of glibenclamide and metformin between the compound metformin hydrochloride and conventional tablets. Results The dissolution rates of glibenclamide and metformin with different preparation came up to the standard of CHP (2005), but the dissolution parameters were different. Conclusion The dissolution rate of glibenclamide indicated significant difference between the compound metformin hydrochloride and the conventional tablets, and no significant difference for metformin.
