Study on the clearance effect of the cross-linked agar entrapping attapulgite clay capsules on the hemoperfusion in vitro
- VernacularTitle:琼脂包嵌凹凸棒微囊体外人全血净化作用研究
- Author:
Xiaolan YANG
;
Yu MA
;
Wei HUANG
;
Cong LUO
- Publication Type:Journal Article
- Keywords:
agar;
attapulgite;
adsorbent;
hemoperfusion
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the adsorptive capacity of cross-linked agar entrapping attapulgite clay (CAA) capsule, a novel adsorbent for hemoperfusion. Methods We selected some drugs such as phenothiazines, methylene blue, and diazepam as the model components to test the adsorptive capacity of CAA in human blood in vitro by means of static stirred absorption experiment and repeated hemoperfusion. Results CAA was of strong adsorption for phenothiazines and methylene blue but of little effect on diazepam. The corresponding adsorptive mechanisms were also discussed here. Conclusion CAA could be used as a highly effective adsorbent for the cation drugs in human blood.
