Significance of Cyclin D1, PCNA, and Ki 67 protein expressions in tissue arrays of patients with recurrent laryngeal carcinoma
- VernacularTitle:CyclinD1、PCNA、Ki67细胞周期相关蛋白在喉复发癌组织芯片中的表达和意义
- Author:
Rui GUO
;
Deliang HUANG
;
Jiaf JI
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasms;
neoplasm recurrence;
protein array analysis;
cell cycles proteins
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognosis of laryngeal cancer postoperative recurrence, and to investigate the relationship of Cyclin D1, PCNA, and Ki 67 protein expression in patients with recurrent laryngeal carcinoma. Methods 574 cases of laryngeal carcinoma from 1958 to 1999 were retrospectively reviewed. All patients were follow up surveyed for 3 years postoperatively. The whole set of tissue microarrays from 574 patients contained tumor tissue, including recurrent tumor tissue from 56 patients, and 39 normal laryngeal tissue specimens from normal laryngeal were collected as control. The tissue chips were analyzed by the SABC immunohistochemical method. Results Cyclin D1, PCNA, and Ki 67 expressed in most of the laryngeal carcinoma and normal laryngeal tissues in a different positive ratio. There was higher expression of Cyclin D1, PCNA, and Ki 67 in recurrent laryngeal carcinoma compared to that in laryngeal carcinoma without recurrence and normal laryngeal tissue ( P
