Effect of traumatic occlusion on the expression of OPG and RANKL mRNA in the rat alveolar bone
- VernacularTitle:咬合创伤大鼠牙槽骨中RANKL和OPG mRNA的表达
- Author:
Hangdong ZHANG
;
Hongchen LIU
;
Jing JIA
- Publication Type:Journal Article
- Keywords:
receptor activator of NF ?B ligand;
osteoprotegerin;
traumatic occlusion
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression change of receptor activator of NF ?B ligand (RANKL) and osteoprotegerin (OPG) mRNA in rat alveolar bone and the possible mechanism of alveolar bone resorption under traumatic occlusion. Methods Thirty SD rats weighed 270g?20g were used and divided into 6 groups, of which one group was as control. A square wire thickened about 1mm was bonded with Super bond composite resin on to the occlusal surface of left upper first molar of the rats in experiment groups. The animals were executed after 1,3,7,14,28 days. The left jaw were processed for the study of the expression of RANKL and OPG mRNA with RT PCR. Results Expression of RANKL and OPG mRNA in alveolar bone was significantly different between experiment and control groups. During occlusal trauma, expression of RANKL and OPG mRNA enhanced in 1 day group. The ratio of RANKL/OPG mRNA expression raised in 1、14 and 28 day groups. Conclusion The ratio of RANKL/OPG mRNA expression changed during occlusion trauma. RANKL and OPG might be involved in the restructure of periodontal tissue after traumatic occlusion
