The karyotype and clinical analysis of 30 cases with Turner syndrome.
- VernacularTitle:特纳综合征30例核型及临床分析
- Author:
Dongxiao CHEN
;
Yiqing CHEN
;
Shenren CHEN
- Publication Type:Journal Article
- Keywords:
Turner syndrome X chromosome Karyotype Menoschesis Microsomia
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research on and analyze the relationship between the clinical situation and karyotype of 30 patients with Turner syndrome (TS).Methods Lymphocytes of peripheral blood were cultured,then karyotyped by G banding and R banding technique.The relationship between clinical situation and karyotype of patients with TS were analyzed.Results The karyotype of TS could be divided into 4 groups:45,XO;mosaicism;with aberration of X chromosome structure and with Y chromosome.The mosaicism was the most popular.The more abnormal karyotype was,the more typical sexual non-development.Conclusion The typical patients with TS had the clinical features of microsomia,menoschesis,sexual non-development and special somatotype.The different clinical features are decided by the degree of abnormal karyotype and the proportion between abnormal cells and normal cells.Besides,the patients with TS who have Y chromosome always show hemaphrodism and must be taken ganadectomy.
