Usefulness of diffusion-weighted and perfusion-weighted MR in mouse C6 gliomas:correlation with histopathology
- VernacularTitle:大鼠C6脑胶质瘤MR扩散加权成像及灌注成像与组织学对照研究
- Author:
Guoguang FAN
;
Peizhuo ZANG
;
Fengdong JING
;
Zhenhua WU
;
Qiyong GUO
- Publication Type:Journal Article
- Keywords:
Glioma;
Magnetic resonance imaging;
Pathology
- From:
Chinese Journal of Radiology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Diffusion/perfusion-weighted MRI (DWI、PWI) was performed to evaluate growth and vascularity of implanted C6 rat gliomas. Methods 36 female Wistar rats were implanted of C6 glioma cells intracerebrally. Between 1 and 4 weeks after implantation, eight to ten different rats were imaged with T_1WI, T_2Weighted imaging, DWI, PWI, and postcontrast T_1WI at each weekly time point. After MRI, each rat brain was examined histologically using HE and immunohistochemical staining for CD34. Results On DWIs, statistical differences of apparent diffusion coefficient (ADC) values for both the solid tumor component and peritumoral region were present comparing 3-4 weeks with 1-2 weeks after implantation (P
