The development of the reversal of the tumor multidrug resistance
- VernacularTitle:肿瘤多药耐药逆转剂的研究进展
- Author:
Chunling DAI
;
Liwu FU
- Publication Type:Journal Article
- Keywords:
multidrug resistance;
P-glycoprotein;
reversal;
tumor;
therapy
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance(MDR)of tumor cells has become the main impediment that influence the curative effect of cancer chemotherapy. Although there are many mechanisms can generate the multidrug resistance, the overexpression of P-glycoprotein encoded by the multidrug resistance-1(mdr1) gene is the main cause in the formation of MDR. Seaching for innocuous and effective reversal of MDR is not only a method of improving the efficiency of cancer chemotherapy but also the problem desiderated to be resolved in chemotherapy domain.
