Cardiomyocyte apoptosis and regeneration in overload cardiac hypertrophy
- VernacularTitle:超负荷心肌肥厚心肌细胞的凋亡和增殖
- Author:
Rui SHENG
;
Zhenlun GU
- Publication Type:Journal Article
- Keywords:
cardiac hypertrophy;
cardiomyocyte;
regeneration;
apoptosis
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
s:Cardiomyocyte apoptosis and regeneration are present in overload cardiac hypertrophy. Cardiac myocyte apoptosis might be a critical factor during the transition from compensatory hypertrophy to heart failure. The mechanisms of apoptosis include extrinsic factors and some cellular signal pathways. On the other hand, cardiomyocyte hyperplasia, as well as hypertrophy, contributes to cardiac hypertrophy. Caridomyocyte regeneration is related to cyclin, cyclin dependent kinase (Cdk), Cdk inhibitors (CdkI), bcl-2, p53 and telomere. Cardiaomyocyte regeneration and apoptosis are linked through several factors.
