Effects of Iptakalim hydrochloride on brain damage and blood rheology after focal cerebral ischemia in rats
- VernacularTitle:盐酸埃他卡林对大鼠局灶性脑缺血后脑组织损伤和血液流变学的作用
- Author:
Wei LIU
;
Ha WANG
- Publication Type:Journal Article
- Keywords:
iptakalim hydrochloride;
focal cerebral ischemia;
erythrocyte membrane fluidity;
blood viscosity;
nimodipine
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the therapeutic effects of Iptakalim hydrochloride on brain damage and blood rheological changes induced by focal cerebral ischemia. Methods The rat model of focal cerebral ischemia was induced by middle cerebral artery occlusion using a suture method. Infarct size was evaluated by TTC staining. Neurological deficit score was evaluated by Longas method. Cerebral water content of the ischemic hemisphere was measured using wet-and-dry-weight method. The erythrocyte membrane fluidity was studied by the fluorescence polarization technique with DPH fluorescence probe. Results Infarct size of the brain was (24.75?6.66)% of contralateral hemisphere 6 h after focal cerebral ischemia.Pretreatment of Ipt 1.0～4.0 mg?kg -1,given inperitoneal,decreased the infarct size by 0.95%,6.6%(P
