Effects of extract of astragalus on hippocampal delayed neuronal death in rats
- VernacularTitle:黄芪提取物对大鼠海马神经元迟发性死亡的影响
- Author:
Weizu LI
;
Liang MING
;
Ting HE
;
Shaobin WANG
;
Weiping LI
- Publication Type:Journal Article
- Keywords:
extract of astragalus (EA);
ischemical and reperfusion injury;
delayed neuron death (DND)
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of extract of astragalus on hippocampal delayed neuronal death of totalcerebral ischemia and 7 days reperfusion in rats.Methods Global ischemia was made by four-vessel occlusion. Electron microscope was used to observe the ultramicrostructure of dorsal hippocampal neurons.Light microscope was used to survey the structure of hippocampal neurons and to count the number of normal neurons in CA1 sector. Glial fibrillary acidic protein(GFAP) was detected by immune histochemistry.Results Compared with ischemia and reperfusion group(I/R),EA improved the ultrastructure of hippocampal neurons, suppressed the decrease of normal neurons in CA1 and degraded the expression of GFAP .The number of normal neurons in I/R group was 38?11.5,and in EA(20,40 mg?kg -1) groups,63?12.8(P
