The establishment of murine model of human Clinical cytomegalovirus interstitial pneumonia
- VernacularTitle:建立人巨细胞病毒小鼠间质性肺炎模型
- Author:
Shu HOU
;
Yating WANG
;
Shuyu XU
- Publication Type:Journal Article
- Keywords:
cytomegalovirus infection;
interstitial pneumonia;
murine model
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To provide experimental basis to study Human Cytomegalovirus(HCMV)infected disease and filtrate anti-virus drugs, HCMV acute interstitial pneumonia murine model was established. Methods Balb/c mice were infected with HCMV AD_ 169 strain. The rate of breath and weight of mice were observed, specific anti-HCMV antibody in serum was detected by ELISA, and viral isolation, Polymerase chain reaction(PCR) and pathological examination of lung tissue were performed aswell. Results Compared with the control group, the rate of breath of mice in the group infected with HCMV increased, while their weight decreased (P
