The role of tubulointerstitial inflammatory cells in human IgA nephropathy
- VernacularTitle:人类IgA肾病间质小管中炎性细胞的研究
- Author:
Guozhen ZHU
;
Rongshan LI
;
Harris DAVID
;
Weimin YU
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis, IgA;
T lymphocyte;
Pathology;
Renal function
- From:
Chinese Journal of Nephrology
1997;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship among interstitial infiltrating inflammatory cells (including CD4+, CD8+, CD25+, MAC387+ and 27E10+), renal function and pathological changes in IgA nephropathy (IgAN). Methods This study included 36 IgAN patients. PAS and immunohistochemistry method were applied to stain paraffin sections. The surface of interstitial tubules, the amount of CD4+, CD8+, CD25+, MAC387+, 27E10 + cells per unit were counted(cells/mm2), together with pathological changes (including glomerulosclerosis, tubular atrophy and interstitial sclerosis) and renal function during and after biopsy were determined by using image analysis system and SPSS software pack. Results In the renal tubulointerstitium, the number of CD4+ cells correlated with interstitial fibrosis (r=0.38 ,P
