Morphologic character of T cells in malignant ascites and pleural effusion
- VernacularTitle:恶性胸、腹水中T细胞类别的形态学特征及其临床意义
- Author:
Tingjun YE
;
Huimin LIU
;
Jisheng JIANG
- Publication Type:Journal Article
- Keywords:
malignant pleural effusion;
malignant ascites;
T lymphocytes;
tumors immunity
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the significance of T cells morphologic character in ascites and pleural effusion in guiding tumor therapy. Methods: Totally 60 ascites and pleural effusion specimens were collected from patients with malignant tumor and were divided into 3 groups: chemotherapy group (18 cases), immunotherapy group (25 cases) and untreated group (17 cases). Ten benign specimens were taken as control.The T cell subtypes in ascites and pleural effusion were analyzed by EnVison~TM immunohistochemistry two-step technique. The T cells were analyzed semi-quantitatively and observed morphologically. Results: The lymphocytes were scattered around tumor cells and formed into petal-like structures. Most tumor cells surrouned by lymphocytes had morphologic changes. The positive rates of CD4, CD8, CD25, CD3, CD45_~RO ,S-100 and CD34 in malignant pleural and ascites effusion of immunotherapy group were significantly higher than those of chemotherapy group and untreated group (P
