Synthesis and antimicrobial activity of substituted pyridine propynyl carbomate compounds
- VernacularTitle:取代吡啶氨基甲酸炔丙酯类化合物的合成和防霉抗菌活性研究
- Author:
Bin YAO
;
Xiaolan SHEN
;
Qianhua YANG
;
Bingxiang XU
- Publication Type:Journal Article
- Keywords:
propynyl carbomate;
synthesis;
antimicrobial agent
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To synthesize substituted pyridine propynyl carbamates and to test their antimicrobial activities. Methods: Eight novel compounds were designed and synthesized. Antimicrobial tests in vitro were carried out with 8 common mildews (Aspergullus niger, Aspergillus flavus, Aspergillus versicolor, Trichoderma viride, Paecilomium varioti Bainier, Chaetomium globsum, Penicillium citrinum, Cladochytrium clodospoium) and 5 bacteria (Escherichia coli, Pseudomonas fluorescens, Bacillus fluorescens, Bacillus megatherium). Results: All compounds synthesized showed antimicrobial activity, especially the compound 1f, whose activity was more potent than that of compound 3-iodo-2-propynyl-butyl-carbamate (IPBC). Conclusion: Compound 1f is worth further studying and exploration.
