Mechanism of M-current modulation by neural transmitters
- VernacularTitle:神经递质调节M电流的机制
- Author:
Qingzhong JIA
;
Hailin ZHANG
- Publication Type:Journal Article
- Keywords:
M-current;
G_( q/11);
intracellular calcium;
membrane phospholipid;
phosphokinase
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
M channel, a voltage-dependent potassium channel, has been found in a variety of neurons. It is activated near the threshold of neuron action potential,producing a primary K~+ current, namely the M-current. The M-current can be modulated by many neurotransmitters and hormones, which can influence neuron excitability, conduction and neurotransmitter release. This review discusses the signal transduction pathway from G_~ q/11 activation to intracellular calcium, membrane phospholipid and phosphokinase, and explains the mechanism of M-current modulation by neurotransmitters.
