Expression of selectin E and P in skin allograft in rats
- VernacularTitle:选择素在大鼠同种异体皮肤移植皮片的表达
- Author:
Junlin WANG
;
Yan JIN
;
Xiaoliang LIU
- Publication Type:Journal Article
- Keywords:
tissue engineering;
selectin E;
selectin P;
immunologic rejection
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the histocompatibility of tissue engineered skin with the observation of the effects of selectins E and P on the immunological rejection after skin allograft in rats. Methods Tissue engineered skin was prepared as follows: The materials obtained from the neonatal SD rats were cultured and then grafted onto the adult Wistar rats. The expression of selectins E and P in the grafted skin was determined with immunohistochemical staining. Results The expression of selectins E and P was significantly higher in the rats with allograft than in the rats with the grafts of tissue-engineered material. Conclusion Selectins E and P play an important role in the immunological rejection after allograft of skin but the tissue-engineered skin graft possesses favorable histocompatibility and shows no obvious immunological rejection.
