Significance of HIF-1? and E-cadherin in cervical carcinoma
- VernacularTitle:缺氧诱导因子-1?及E-钙粘蛋白在宫颈癌中的表达及意义
- Author:
Shuang LIN
;
Li LI
;
Yun WANG
- Publication Type:Journal Article
- Keywords:
uterine cervix;
carcinoma;
hypoxia inducible factor-l (HIF-1?);
E-cadherin
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of the expressions of HIF-1? and E-cadherin in cervical carcinoma. Methods The expressions of HIF-1? and E-cadherin (E-cad) were determined in the clinical specimens of 109 cases of cervical carcinoma, 16 cases of cervical intraepithelial neoplasm and 10 cases of normal cervical tissue with immunohistochemical assay. Results There was nearly no expression of HIF-1? in the normal cervical tissue. The positive expression of HIF-1? and E-cad were 81.4% (70/86) and 28.6% (25/86) respectively in the tissue of invasive cervical carcinoma. The rate of positive expression of HIF-1? was significantly higher in invasive cervical carcinoma than in normal cervical tissue and cervical intraepithelial neoplasm (P
