Efficacy of freeze-dried M. vaccae vaccine in treatment of patients with multi-drug resistant pulmonary tuberculosis
- VernacularTitle:冻干治疗用母牛分支杆菌菌苗对耐多药肺结核患者临床疗效及细胞免疫功能的影响
- Author:
Weimin DING
;
Junxing YANG
;
Guanghui WANG
- Publication Type:Journal Article
- Keywords:
pulmonary tuberculosis;
multi-drug resistant;
immunotherapy;
cellular immune function;
T-lymphocyte subsets;
M.vaccae
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the immunotheraptical drugs for multi-drug resistant pulmonary tuberculosis (MDR-TB). METHODS: 79 patients with MDR-TB were randomly assigned to two groups. 46 cases in M.vaccae group were treated with "3AkPaThLevL/15PaThLevL" and M. vaccae, and 33 cases in control group were treated only with "3AkPaThLevL/15PaThLevL". The clinical effect and T-lymphocyte subsets in patients were observed after being treated for 1,2 and 3 months, respectively. RESULTS: The sputum negative rates ((41.3)%, (63.0)%, and (80.4)%) and the X-ray resolution rates ((30.4)%, (50.0)%, and (67.4)%) of the M.vaccae group were superior to those ((12.1)%, (27.3)%, and (39.4)%, P
