Induction chemotherapy combined with three-dimensional conformal radiation ther a py for locally advanced non small cell lung cancer
- VernacularTitle:诱导化疗加三维适形放疗治疗局部晚期非小细胞肺癌疗效分析
- Author:
Aiqing ZHENG
;
Jinming YU
;
Xianguang ZHAO
;
Xuetao WANG
;
Guangsheng WEI
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell Lung/radiotherapy;
Radiotherapy, conformal;
Carcinoma,non-small cell Lung/chemotherapy
- From:
Chinese Journal of Radiation Oncology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect and complication of inductio n chemot herapy combined with three-dimensional conformal radiation therapy (3DCRT) for l ocally advanced non small cell lung cancer (NSCLC). Methods Ninety-two such pa t ients were randomized into radiation therapy alone group(RT-, 50 patients) and i nduction chemotherapy combined radiotherapy group (CMT-, 42 patients). The indu c tion chemotherapy consisted of 2-4 cycles of platinum-based regimen. Results Th e overall median survival time was 15 months with 12 months in the RT group and 18 months in the CMT group(P=0.014)respectively. The 1-year o verall survival rates were 48.6% and 71.2% in RT and CMT group,respectively (P=0.004). The 2-year survival rates w ere 20.8% and 37.6% in RT and CMT group, respectively (P=0.0 41). Treatment was w ell tolerated and the toxicities were similar in either group. C onclusion The ad dition of induction chemotherapy to 3DCRT takes a survival advantage over 3DCRT alone for Stage Ⅲ NSCLC without increasing toxicities.
