Inhibition effects of asiaticoside on controlling capsule formation around breast implant in rats
- VernacularTitle:积雪草甙对大鼠乳房假体包膜形成影响的实验研究
- Author:
Xia DAI
;
Shirong LI
- Publication Type:Journal Article
- Keywords:
capsular contracture;
asiaticoside;
breast implants;
fibroblasts
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential role of asiaticoside in controlling the capsular formation around breast implant in rats. Methods Forty female Sprague-Dawley rats were implanted with 2 silicone elastomer in bilateral dorsal interscapular region subcutaneously each, and randomly assigned to 2 groups (n=20 in each group): control group and experimental group. The experimental group was of intragastric administration with asiaticoside (24 mg/kg) daily while control group with saline of identical volume. On day 7, 14, 28, 56 and 84, 4 rats from each group were sacrificed. Specimens were collected for HE staining. Image-pro Plus was applied to measure the thickness of capsule at different time intervals and the dynamic alteration in histology was observed. Results In experimental group, the formation of capsule ended up with a thickness of (194.33?23.27)?m, dramatically thinner than that of control group (306.08?31.31)?m (P
