Enhancing blood flow of necrotic femoral head by adenovirus hu-VEGF_(121) transfection in rabbits
- VernacularTitle:Ad-huVEGF_(121)基因转染对兔坏死股骨头血流的影响
- Author:
Yong JIA
;
Tongwei CHU
;
Yue ZHOU
;
Gang LUO
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor;
femoral head necrosis
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore a new method for the therapy of vascular necrosis of the femoral head. Methods The recombinant Ad-huVEGF 121 was implanted into the necrotic femoral head. The expression of vascular endothelial growth factor (huVEGF 121 ) was examined by RT-PCR and immunohistochemical techniques. Angiogenesis was observed by histomorphometric analysis and blood flow of femoral head was observed by SPECT. Results The expression of huVEGF 121 was detected in the femoral head transfected with the huVEGF 121 gene. The femoral head transfected with the huVEGF 121 gene showed a significant increase in angiogenesis and blood flow of femoral head after gene transfection. Conclusion Transfection of the VEGF 121 gene enhances angiogenesis of bone tissue and blood flow of necrotic femoral head.
