The effect of bisoprolol on action potential duration (APD) and K~+ current in ventricular myocytes after myocardial infarction
- VernacularTitle:比索洛尔对心肌梗死后心室肌细胞动作电位时程及钾电流的影响
- Author:
Bing LIU
;
Rongqing ZHANG
;
Haichang WANG
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
action potential duration;
transient outward K + current (I to);
inward rectifier K + current(I K1);
bisoprolol
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of action potential duration (APD) and transient outward K + current (I to) and inward rectifier K + current(I K1) of ventricular myocytes after 3 weeks of myocardial infarction, and to inquire into the effect of bisoprolol. Methods APD was recorded with microelectrode. Ventricular myocytes were singly isolated from rabbit heart using modified Langendoff perfusion and soaked with collagenase. I to and I K1 of single rabbit ventricular myocytes were recorded by whole-cell path-clamp technique. Results Both APD 50 and APD 90 of the cell from noninfarcted region in MI group were markedly longer than that in sham group (P
