Differential expression of integrin alpha 6 in endometrium and endometriosis
- VernacularTitle:整合素?6在子宫内膜异位症中的表达分析
- Author:
Ting LI
;
Yali LI
;
Jianmin LI
- Publication Type:Journal Article
- Keywords:
endometriosis;
integrin ?6;
gene expression
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the distribution and expression of integrin alpha 6 in eutopic and ectopic endometriosis, and to approach the significance of integrin alpha 6 in this illness. Methods Endometria, focal tissues and fresh tissues were collected from patients with or without endometriosis and normal individuals, respectively. RT-PCR, immunohistochemistry, Western-blot and flow cytometry were employed to assay the distribution and expression of integrin alpha 6 in those collected samples. Results The expression of integrin alpha 6 subunit in proliferative phase and secretive phase has no statistical difference in the patients with or without endometriosis, while the expression of integrin alpha 6 subunit was down-regulated in the ectopic endometrium compared with that in the eutopic counterpart. Conclusion The pathogenesis of endometriosis involves complex regulation of both functions and expression of integrins. The down-regulated expression of integrin alpha 6 in ectopic endometrium may associated with endometriosis.
