The effects of radiation-induced heart injury on cardiac troponin I and endothelin-1 and the preventive and therapeutic effect of fluvastatin
- VernacularTitle:心脏辐射损伤对心肌肌钙蛋白Ⅰ和内皮素-1的影响及氟伐他汀的防治作用
- Author:
Fengyun FAN
;
Bingfang ZHANG
;
Jiangfeng YE
- Publication Type:Journal Article
- Keywords:
radiation-induced heart injury;
cardiac troponin I;
endothelin-1;
fluvastatin
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of radiation-induced heart injury on cardiac troponin I (cTnI)and endothelin-1(ET-1) and observe the preventive and therapeutic effect of fluvastatin. Methods Healthy female SD rats were randomly divided into three groups: control group(c), irradiation alone group(R) and fluvastatin therapeutic group (F). Rats of F group had been gastrogavaged with fluvastatin at dose of 20mg?kg -1?d -1 from 1week before irradiation to the end of the experiment. In C group and R group, rats were gastrogavaged with the same volume isotonic sodium chloride. The rats of R and F group were irradiated with accelerator linear at a dose of 20Gy thoracically. Rats were executed at 5,15,30d and 60d after irradiation, then cTnI in serum and ET-1 in blood plasma were detected. Results On 5d, the content of cTnI in R group increased significantly than that in C group(P
