Effect of X-ray on amino-acid transmitters in brain of epileptic rat
- VernacularTitle:X线照射对实验性癫痫大鼠脑皮层氨基酸递质含量的影响
- Author:
Shuli LIANG
;
Anmin LI
;
Junyou LI
- Publication Type:Journal Article
- Keywords:
gamma-aminobutyric acid;
Glutamic acid;
epilepsy;
X-ray therapy
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effective mechanism, time and rational dose of radiotherapy of epileptic rat. Methods To make rat model of epilepsy, and give 0, 24,12 or 6Gy X ray irradiation, and then detect the amino-acid contents in frontal lobe of those rats in 1 hour, 24 hours or 1 week after radiotherapy. Results Glu and GABA are the key amino-acids in radio effection. After 12Gy or 24Gy irradiation there were low Glu, high GABA and low Glu/GABA in frontal lobe of rat. After 1h, 24h and 1 week irradiation, the contents of GABA raised up while the ratio of Glu/GABA declined with a remarkable decline at 24h. Conclusions Radiotherapy to epileptic rat may set off a rapid and enduring change of GABA and Glu transmitters, and 12Gy may be the rational radio dose for epileptic rat.
