Characteristics of circulating type 2 pre-dendritic cells(pDC2)and lymphocyte subsets in chronic hepatitis B patients accepting antiviral therapy
- VernacularTitle:抗病毒治疗对慢性乙型肝炎患者Ⅱ型树突状细胞及淋巴细胞亚群的影响
- Author:
Xuezhang DUAN
;
Fusheng WANG
;
Min WANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B, chronic;
Dendritic cells;
T- Lymphocyte subsets;
Antiviralagents
- From:
Chinese Journal of Infectious Diseases
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify impacts of antiviral therapy on the frequency and interferon (IFN)-?-producing ability of circulating type 2 pre-dendritic cells(pDC2)as well as lymphocyte subsets in patients with chronic hepatitis B virus (HBV)infection. Methods Thirty-three patients with chronic HBV infection and 25 healthy individuals as controls were enrolled in our study. Two kinds of drugs, lamivudine and IFN-?, were used in antiviral regimen respectively. Absolute numbers of circulating pDC2 and lymphocyte subsets were analyzed by flow cytometry consecutively. The IFN-?-producing function of peripheral blood mononuclear cells (PBMCs) representing the circulating pDC2 was determined by ELISA assay. Results In patients with chronic HBV infection, the frequency and function of pDC2 decreased compared with those found in healthy controls. After antiviral treatment for 6 months, lamivudine seemed to induce the increase of frequency and absolute number of pDC2. The absolute numbers of peripheral CD8~+ T-cells and NK cells were simultaneously found to ascend. A similar result was also observed in chronically HBV-infected humans with 6 months duration of IFN-? therapy. Conclusions Our results showed that lamivudine or IFN-? antiviral treatment could increase the number of peripheral pDC2 and CD8~+ T-cells in the patients with chronic HBV infection.
