Effects of omapatrilat on renal tubulointerstitial fibrosis in 5/6 subtotal nephrectomized rats
- VernacularTitle:omapatrilat对5/6肾切除大鼠肾小管间质病变的影响
- Author:
Shengchuan DAI
;
Weiming WANG
;
Bin ZHANG
;
Nan CHEN
- Publication Type:Journal Article
- Keywords:
Nephrectomy;
Fibrosis;
Renal tubulomterstitium;
Omapatrilat
- From:
Chinese Journal of Nephrology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of vasopeptidase inhibitors (VPi) omapatrilat on renal tubulointerstitial fibrosis of 5/6 subtotal nephrectomized rats and to explore new prevention and treatment of renal lubulointerstitial fibrosis.Methods The renal subtotal ablation model was established by surgical 5/6 renal resection in male SD rats.Five animal groups included(1)STN group (subtotal nephreclomy); (2)Omap 10 mg group (10 mg?kg-1?d-1); (3)Omap 40 mg group (40 mg?kg-1?d-1) ; (4)Sham group and (5)Nornial control. Systolic arterial BP and renal function were measured periodically.Animals were sacrificed at the end of the 12th week after operation. Tubulointerstitial injury was scored semiquantitatively by morphological analysis (HE, Masson, PAS and PASM stain). Results Significant tubulointerstitial injury was noted in the STN group compared with normal group and sham group (P
