Expression of ANGPTL3 in kidney and its relationship to proteinuria and hyperlipidemia in adriamycin-induced nephrotic rats
- VernacularTitle:阿霉素肾病大鼠肾组织中血管形成素样蛋白3表达与蛋白尿及高脂血症的关系
- Author:
Jianwen WU
;
Hong XU
;
Ying WU
;
Liewei ZHU
;
Lian CHEN
- Publication Type:Journal Article
- Keywords:
Nephrotic syndrome;
Model,animal;
Angiopoietin-like protein
- From:
Chinese Journal of Nephrology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression and distribution of angiopoietin-like protein 3(ANGPTL3) in kidney of adriamycin(ADR)-induced nephrotic rats, and to explore the possible association of ANGPTL3 with the development of proteinuria and hyperlipidemia. Methods Adriamycininduced nephrotic rat models were established by a single injection of adriamycin via the tail vein. Immunohistochemical staining (IHS)and dot-ELISA were used to examine the expression and distribution of ANGPTL3 in kidney and the level of ANGPTL3 in serum of ADR rats at day 7,14, 21 and 28 after adriamycin injection. Results (1) In ADR rats, urinary protein and the level of triglyceride and cholesterol in serum increased significantly at day 14 (P
