The biology and potential clinical application of bone marrow-derived stem cells
- VernacularTitle:骨髓来源的干细胞及其应用前景
- Author:
Jianmin WANG
;
Rong XIA
- Publication Type:Journal Article
- Keywords:
bone marrow;
stem cells;
biology;
plasticity;
clinical application
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow-derived stem cells, mainly including hematopoietic stem cells, mesenchymal stem cells, multipotent adult progenitor cells, etc., are the most densely studied adult stem cells up to now. Recent findings indicate that adult stem cells have the potential to differentiate across lineage barriers and to adopt the expression profiles and functional phenotypes of cells unique to other tissues. This flexibility is termed "plasticity",which has posed challenges to conventional concepts. Meanwhile, it brings new hopes for the therapeutic application of cell engineering and tissue engineering. This review focuses on the biological features, the plasticity and its possible mechanisms, research method and potential clinical application of bone marrow-derived adult stem cells
