Preliminary study of the correlation of neovascularization in cornea after cautery with acid and the epithelial defect, the infiltrating of leucocytes
- VernacularTitle:角膜酸烧伤后新生血管形成与上皮缺损和白细胞渗出关系的初步研究
- Author:
Hong WANG
;
Hanping XIE
;
Xu YIN
;
Zhimin LIU
- Publication Type:Journal Article
- Keywords:
cornea;
epithelium;
neovascularization;
leucocytes;
acid burn
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between corneal neovascularization (CNV) in rat after cautery with acid and the defect in epithelium, the infiltrating of leucocytes. Methods The model of mild, moderate and severe acid burn in rat cornea was established. Corneal angiogenesis and the diameter of the epithelial defect were observed with a slit lamp microscope. The ratio of neovascularization area to that of cornea was calculated. The specimens were taken to stain with hematoxylin and eosin (HE) at different time points after cautery and the number of the leucocytes in cornea was calculated with light microscope. The relation between CNV and the diameter of epithelial defect and the infiltrating leucocytes in cornea was analyzed with Pearson's correlation. Results The healing of epithelium differed with different degree of acid burn. The more damage the eye suffered, the more time it would take to heal. Leucocytes infiltrated in cornea after cautery. The more damage the eye suffer, the more leucocytes can be observed, and the statistical difference was significant (P
