The mechanisms of glutamate release in cerebral ischemia
- VernacularTitle:脑缺血时谷氨酸释放机制
- Author:
Heshan MEI
;
Yongli WANG
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
?-aminobutyric acid receptors;
glutamate;
glutamate transporter;
metabotropic glutamate receptors;
cystine-glutamate exchanger
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Glutamate is a major excitatory neurotransmitter in the central nervous system(CNS)and plays an important role in neuronal damage induced by cerebral ischemia. Several mechanisms contribute to modulation of glutamate release during cerebral ischemia, such as vesicular release dependent on calcium, release by reversed operation of glutamate transporters, release through swelling-activated anion channel and receptor-modulating release, etc. This review addresses the mechanisms of glutamate release during cerebral ischemia.
