Applications of RNA interference technology to drug study
- VernacularTitle:RNA干扰技术在药物研究中的应用
- Author:
Xinping LI
- Publication Type:Journal Article
- Keywords:
RNA interference;
drug study
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
RNA interference is a mechanism of posttranscriptional gene silencing(PTGS) induced by double-stranded RNA. dsRNA is firstly degradated into 21-23 nt siRNA by Dicer RNase, and then makes itself as a template, triggers sequence-specific mRNA to degradate at the specific site and the specific time. Along with the deep study and the wide application of RNAi, RNAi technology can be used to address certain bottlenecks during preclinical drug development.Such technologies currently are being used to help identify the best drug targets for a given disease indication. An emerging and potentially powerful application of these technologies is now being explored to help prioritize drug candidates to lessen cost and time consuming preclinical animal studies. Effective implementation of RNAi technology during preclinical drug development can increase the probability of success and accelerate the path to the clinic. and provide emerging and potentially powerful tools for drug study.
