Effects of 11,12-EET on the expression of phophorylatedJNK1/JNK2 in ischemic and reperfusion rat heart
- VernacularTitle:11,12-EET对在体大鼠正常及再灌注心肌JNK1/JNK2表达的影响
- Author:
Gang HAO
;
Hongxia WANG
;
Lingqiao LU
;
Xiangjun ZENG
;
Like ZHANG
- Publication Type:Journal Article
- Keywords:
epoxyeicosatrienoic acid;
reperfusion injury;
precondition;
c-Jun N-terminal protein kinase
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the expression of phosphorylated JNK1/JNK2 and the protection of 11,12-EET in ischemic and reperfusion rat heart.Method The expression of JNK1/JNK2 was detected with western blot method and the changing of heart function during ischemia/reperfusion process was observed in different groups. Results The cardiac function (+dp/dt_(max)%,-dp/dt_(max)% and LVDP)of reperfusion periods(30 min) apparently decreased in ischemia/reperfusion (I/R) group contrasted with Sham group, short ischemia(SI)+I/R group and EET+I/R group,and the expression of phosphorylated JNK1/JNK2 increased in I/R group contrasted with nromal group,Sham group and EET+I/R group.Conclusion The myocardial protection of 11,12-EET ( 6.24?10~(-8) mol?L~(-1)) is able to inhibit the expression of phosphorylated JNK1/JNK2.
