The protective effects of melatonin on acute ischemia/reperfusion induced myocardium damage in rats in vivo
- VernacularTitle:褪黑素对在体大鼠心肌缺血再灌注损伤的作用
- Author:
Kaifu WEI
;
Yexin MA
;
Yingzhong LIN
- Publication Type:Journal Article
- Keywords:
melatonin;
ischemia-reperfusion;
myocardium
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the protective effects of MLT(melatonin) on acute ischemia-reperfusion induced myocardium damage in rats in vivo. Methods 36 anesthetized rats were separated randomly into 3 groups: ① Control group (n=12), without LAD (left anterior descending coronary artery) ligation and MLT; ② I/R(ischemia reperfusion) group(n=12), LAD was ligated for 10 min and reperfused for 15 min without MLT; ③ I/R+MLT group(n=12): MLT(10 mg?kg~(-1)) was in jected via peritonium 10 minutes before LAD ligation and reperfusion. ECG and haemodynamics were continuously monitored and recorded throughout the whole process, MDA(malondialdehyde, lipid peroxidation product, an index of myocardium damage) and SOD( superoxide dismutase ) activity were tested in the injuried myocardium. The hearts tissue of each group was also examinated by electron microscopy.Result The levels of MDA were significantly higher while the SOD activities were lower in I/R group compared with I/R+MLT and control group(P0.05). The haemodynamics indices of contractile and diastolic functions were also better in I/R+MLT group than inI/R group(P
