Relationship between transforming growth factor-?_1 signal transduction and renal fibrosis of diabetes
- VernacularTitle:糖尿病肾病中转化生长因子-?_1信号转导与肾纤维化
- Author:
Jianyun WANG
;
Xiaoxing YIN
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
transforming growth factor-?_1;
renal fibrosis;
Smads;
MAPK
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy is one of the leading causes of the end-stage renal failure, and its major pathologic feature is the renal fibrosis. Transforming growth factor-?_1 is a key factor in the progression of the disease. Two signal pathways, Smads and MAPK following the factor, are closely connected with extracellular matrix accumulation which leads to renal fibrosis. Smads and MAPK also have a cross talk in extracellular matrix accumulation. The relationship between the two signal pathway and ECM accumulation offers us a new therapeutic strategy for renal fibrosis of diabetes.
